How we change what others think, feel, believe and do
Seratonin, or 5-hydroxytryptamine (5-HT), is a monoamine. Its adjective is serotonergic.
Chemically, seratonin is created in seratonergic neurons in the CNS.
Seratonin provides a wide range of control of emotions and the body, including anger, aggression, body temperature, pain, mood, sleep, dreaming, human sexuality, appetite, and metabolism. It also stimulates vomiting.
A common pattern in some seratonin-involved activities appears to be compulsion and urge. In other words, seratonin motivates. Happy people are motivated and so create seratonin, rather than, as is sometimes thought, that happiness is caused by seratonin, though elevated levels can lead to happiness through the motivating effect.
Seratonin has also been linked with contentment and satisfaction. Sadness is related to a lack of seratonin.
There are drugs that are amplifying agonist and blocking antagonist for all types of serotonergic receptors.
p-chlorophenyalanine (PCPA) is an antagonist, blocking the effect of TPH.
Fluoxetine (Prozac) inhibits reupdate of seratonin and is used in treatment of depression, anxiety and
Fenfluramine stimulates the release of seratonin and is used as an appetite suppressant in treating obesity.
Methylenedioxymethamphetamine (MDMA) or 'Ecstasy' has excitatory and hallucinogenic and is an agonist for both seratonin and norepinephrine. It makes noradrenergic and serotonergic transporters to operate backwards, increasing neurotransmitter release and inhibiting reupdate. MDMA action on sertonoergic transporters causes hallucinations but can also damage them.